Description

4,4'-Dimethoxy-3''-Fluorotrityl Alcohol is a specialized trityl-protecting group reagent with a fluorine substituent, offering enhanced stability and selectivity in complex organic syntheses. This compound is critical for the protection of hydroxyl groups, particularly in the multi-step synthesis of sensitive pharmaceutical intermediates and oligonucleotides. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors where high-purity, functionalized building blocks are required.

Application

• Pharmaceutical Intermediate Synthesis: As a key protecting group reagent for hydroxyl functions in the production of active pharmaceutical ingredients (APIs) and nucleoside analogs.
• Oligonucleotide and Peptide Chemistry: For the selective protection of sugar hydroxyls during solid-phase synthesis of DNA/RNA fragments and complex peptides.
• Agrochemical Research: Employed in the development and scale-up of novel pesticides and herbicides requiring selective protection-deprotection strategies.
• Fine Chemical Manufacturing: Serves as a crucial building block for synthesizing fluorinated organic compounds and specialty chemicals.
• Academic & Industrial R&D: Used in methodological development for organic synthesis and catalysis studies within university and corporate laboratories.
• Material Science: Potential application in the synthesis of monomers for advanced polymers and functional materials.

Basic Information

Product Name	4,4'-Dimethoxy-3''-Fluorotrityl Alcohol
CAS No.	342045-54-9
Molecular Formula	C21H19FO3
Molecular Weight	338.37 g/mol
Synonyms	3''-Fluoro-4,4''-dimethoxytrityl alcohol; DMT-F Alcohol; 3-Fluoro-4,4'-dimethoxytrityl alcohol; 3''-F-DMT-OH; (3-Fluorophenyl)bis(4-methoxyphenyl)methanol; 3-Fluoro-4,4'-dimethoxytriphenylmethanol; 3-F-DMTr-OH; Fluorinated DMT Protecting Reagent
EINECS	Contact for details

Quality Control

Our 4,4'-Dimethoxy-3''-Fluorotrityl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in GMP-oriented environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to moisture. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.