Description

1-(Trimethylsilyldifluoromethyl)-1H-Imidazole is a specialized organosilicon reagent featuring a reactive difluoromethyl group. This compound is valued for its role as a versatile building block in the synthesis of complex fluorinated molecules, which are critical in advanced material and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for introducing fluorinated motifs.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated or silicon-containing scaffolds to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where fluorination enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or modifying agent in the synthesis of specialty polymers, coatings, and silicon-based materials with unique surface properties.
• Fluorination Reagent: Acts as a source of the -CF2- group in organic synthesis, enabling the introduction of difluoromethylene units into target molecules under mild conditions.
• Ligand and Catalyst Development: Employed in the preparation of novel N-heterocyclic carbene (NHC) precursors and other ligands for catalytic systems.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed and other metal-mediated coupling reactions to construct complex molecular architectures.

Basic Information

Product Name	1-(Trimethylsilyldifluoromethyl)-1H-Imidazole
CAS No.	341529-07-5
Molecular Formula	C7H12F2N2Si
Molecular Weight	202.27 g/mol
Synonyms	1-[(Difluoromethyl)dimethylsilyl]-1H-imidazole; 1H-Imidazole, 1-[(difluoromethyl)dimethylsilyl]-; (Difluoromethyl)dimethyl(1H-imidazol-1-yl)silane; TMS-CF2-Imidazole; Trimethylsilyldifluoromethyl Imidazole; 1-(Difluoromethyl-dimethyl-silanyl)-1H-imidazole; N-[(Difluoromethyl)dimethylsilyl]imidazole
EINECS	Contact for details

Quality Control

Our production of 1-(Trimethylsilyldifluoromethyl)-1H-Imidazole adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Every lot is fully characterized and tested against established specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.