Description

Dl-Tryptophan-2,3,3-D3 is a stable isotope-labeled analog of the essential amino acid tryptophan, specifically deuterated at the 2,3,3 positions. This compound is a critical tool for advanced analytical research, enabling precise quantification and metabolic pathway tracing in complex biological systems. It is primarily utilized by research institutions, pharmaceutical developers, and contract research organizations (CROs) engaged in mass spectrometry-based proteomics, metabolomics, and pharmacokinetic studies.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a quantitative reference standard in LC-MS/MS and GC-MS analyses for accurate measurement of endogenous tryptophan levels.
• Metabolic Pathway Tracing: Used in stable isotope labeling (SIL) experiments to study amino acid metabolism, protein synthesis rates, and neurotransmitter (serotonin) biosynthesis pathways.
• Pharmaceutical Research & Development: Facilitates drug metabolism and pharmacokinetic (DMPK) studies by acting as an internal standard for bioanalytical method development and validation.
• Clinical Diagnostics Research: Employed in developing assays for metabolic disorders related to tryptophan catabolism, such as in kynurenine pathway analysis.
• Nutritional Science Studies: Used in research investigating protein digestion, amino acid absorption, and isotopic tracer studies in nutritional biochemistry.
• Proteomics & Biomarker Discovery: Integral to stable isotope labeling by amino acids in cell culture (SILAC) and other quantitative proteomics techniques for relative and absolute protein quantification.

Basic Information

Product Name	Dl-Tryptophan-2,3,3-D3
CAS No.	340257-61-6
Molecular Formula	C₁₁H₁₀D₃N₂O₂
Molecular Weight	207.24 g/mol
Synonyms	DL-Tryptophan-2,3,3-d3; (RS)-Tryptophan-2,3,3-d3; 2-Amino-3-(3-indolyl)propionic-2,3,3-d3 acid; Tryptophan-d3 (2,3,3 positions); (±)-Tryptophan-2,3,3-d3; Indole-3-alanine-2,3,3-d3; 1H-Indole-3-propanoic-2,3,3-d3 acid, α-amino-; 340257-61-6
EINECS	Contact for details

Quality Control

Our Dl-Tryptophan-2,3,3-D3 is manufactured under strict quality management systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity, isotopic enrichment, and chromatographic profile. We support research requiring compliance with various pharmacopeial standards and can provide material suitable for use as a certified reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.