Description

2-(Fmoc-Amino)Ethyl Bromide is a specialized, high-purity building block designed for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise and reliable reagents for constructing complex molecules. It is primarily utilized in the pharmaceutical and biotechnology sectors for solid-phase peptide synthesis (SPPS) and the development of novel drug candidates and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key reagent for the introduction of the Fmoc-protected aminoethyl linker, enabling the attachment of peptides to solid supports.
• Linker Chemistry: Used in the synthesis of various linkers and spacers for bioconjugation, particularly in antibody-drug conjugates (ADCs) and targeted therapeutics.
• Protecting Group Strategy: The Fmoc (9-fluorenylmethoxycarbonyl) group provides orthogonal protection for amines, making this reagent essential in multi-step synthetic routes common in medicinal chemistry.
• Biomolecule Modification: Facilitates the alkylation of nucleophiles such as thiols and amines on proteins, nucleic acids, or other biomolecules for labeling and functionalization.
• Combinatorial Library Synthesis: A valuable building block for creating diverse chemical libraries for high-throughput screening in drug discovery.
• Material Science: Can be employed in the surface functionalization of polymers and nanomaterials to introduce reactive amine handles.

Basic Information

Product Name	2-(Fmoc-Amino)Ethyl Bromide
CAS No.	340187-12-4
Molecular Formula	C₁₇H₁₆BrNO₂
Molecular Weight	346.22 g/mol
Synonyms	2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]ethyl Bromide; N-Fmoc-2-bromoethylamine; 2-Bromoethyl (9-Fluorenylmethyl)carbamate; Fmoc-NH-CH2-CH2-Br; 2-(Fmoc-amino)ethyl bromide; N-(2-Bromoethyl)-9H-fluoren-9-ylmethoxycarboxamide; 2-Bromoethylamine, N-Fmoc-; Fmoc-2-aminoethyl bromide
EINECS	Contact for details

Quality Control

Our 2-(Fmoc-Amino)Ethyl Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and cGMP manufacturing environments. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.