Description

(R)-tert-Butyl 2-Vinylpyrrolidine-1-Carboxylate is a high-value, chiral building block and key intermediate in organic synthesis. Its primary importance lies in its role as a versatile precursor for the construction of complex, biologically active molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel therapeutics, agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of protease inhibitors, kinase inhibitors, and other small-molecule drugs.
• Asymmetric Synthesis: Used as a starting material or auxiliary in asymmetric catalytic reactions and chiral pool synthesis to introduce stereogenic centers.
• Agrochemical Research: Serves as a building block for the development of novel, chiral pesticides and herbicides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Employed in the preparation of novel chiral ligands and organocatalysts for use in enantioselective transformations.
• Peptidomimetics and Proline Derivatives: The vinylpyrrolidine core is a valuable scaffold for creating peptidomimetics and modified proline analogs used in drug discovery.
• Material Science: Potential monomer or precursor for specialized polymers and advanced functional materials requiring specific chiral architectures.

Basic Information

Item	Detail
Product Name	(R)-tert-Butyl 2-Vinylpyrrolidine-1-Carboxylate
CAS No.	340129-94-4
Molecular Formula	C11H19NO2
Molecular Weight	197.27 g/mol
Synonyms	(R)-1-Boc-2-Vinylpyrrolidine; (R)-N-Boc-2-Vinylpyrrolidine; (R)-tert-Butyl 2-Ethenyl-1-pyrrolidinecarboxylate; (R)-2-Vinyl-1-(tert-butoxycarbonyl)pyrrolidine; (R)-1-(tert-Butoxycarbonyl)-2-vinylpyrrolidine; (R)-N-(tert-Butoxycarbonyl)-2-vinylpyrrolidine; Boc-(R)-2-Vinylpyrrolidine
EINECS	Contact for details

Quality Control

Every batch of (R)-tert-Butyl 2-Vinylpyrrolidine-1-Carboxylate is produced and tested under strict quality management systems to ensure high chemical and chiral purity, meeting the exacting standards of research and development. Our quality assurance includes comprehensive analytical characterization using HPLC, GC, NMR, and chiral analysis. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.