Description

8-Hydroxyhydromorphone is a high-purity synthetic opioid derivative, specifically a hydroxylated metabolite of hydromorphone. This compound is of significant interest in advanced pharmaceutical research and analytical chemistry, serving as a critical reference standard and a key intermediate in the development of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and forensic analysis facilities for method development, metabolite identification, and quality control of related pharmaceutical products.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of hydromorphone and its metabolites in drug development and bioanalytical studies.
• Metabolite Research: Serves as a critical analytical standard for studying the metabolic pathways, pharmacokinetics, and pharmacodynamics of hydromorphone in preclinical and clinical research.
• Forensic Toxicology: Employed as a calibrant and control in forensic laboratories for the accurate identification and quantification of opioid substances and their metabolites in biological samples.
• Impurity Profiling: Essential for the identification and control of process-related impurities and degradation products during the manufacturing and stability testing of hydromorphone-based pharmaceuticals.
• Biochemical Research: Used as a tool compound in receptor binding assays and studies investigating the structure-activity relationships (SAR) of opioid receptor ligands.
• Method Development & Validation: A key component in developing and validating sensitive analytical methods, such as HPLC, LC-MS/MS, and GC-MS, for opioid analysis.

Basic Information

Product Name	8-Hydroxyhydromorphone
CAS No.	339525-94-9
Molecular Formula	C17H19NO4
Molecular Weight	301.34 g/mol
Synonyms	8-Hydroxyhydromorphone; 8-Hydroxy-4,5α-epoxy-3-hydroxy-17-methylmorphinan-6-one; Hydromorphone-8-ol; 8-OH-Hydromorphone; 8-Hydroxydihydromorphinone; 8-Hydroxy-4,5-epoxy-17-methylmorphinan-3,6-diol
EINECS	Contact for details

Quality Control

Our 8-Hydroxyhydromorphone is manufactured under strict quality management systems to ensure the highest standards of purity and consistency. Each batch is subjected to comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of residual solvents. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications suitable for research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.