Description

5-Phthalimido-3-Pentyne is a high-purity, specialized organic building block featuring a terminal alkyne group protected by a phthalimide moiety. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in click chemistry and peptide coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of complex drug candidates, especially those utilizing Huisgen cycloaddition (click chemistry) for bioconjugation.
• Agrochemical Research: Used in the development of new pesticides and herbicides by serving as a synthon for introducing alkyne functionality into target molecules.
• Peptide Chemistry: Acts as a protected alkyne-amino acid derivative for the solid-phase synthesis of modified peptides and peptidomimetics.
• Material Science: Employed in the creation of functionalized polymers, dendrimers, and surface coatings through controlled polymerization or grafting techniques.
• Bioconjugation & Probe Development: Facilitates the labeling of biomolecules (proteins, antibodies, nucleic acids) with fluorescent dyes or other reporter groups via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Chemical Biology Tool: Serves as a versatile handle for activity-based protein profiling (ABPP) and the development of chemical probes to study biological pathways.

Basic Information

Product Name	5-Phthalimido-3-Pentyne
CAS No.	339310-24-6
Molecular Formula	C₁₃H₁₁NO₂
Molecular Weight	213.23 g/mol
Synonyms	5-(1,3-Dioxoisoindolin-2-yl)pent-2-yn-1-amine; 2-(4-Aminobut-2-yn-1-yl)isoindoline-1,3-dione; N-(4-Aminobut-2-ynyl)phthalimide; 5-Phthalimidopent-2-yne; Propargylamine derivative, phthalimide-protected; 4-(Phthalimido)-2-butyn-1-amine; 2-Butyn-1-amine, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
EINECS	Contact for details

Quality Control

Our 5-Phthalimido-3-Pentyne is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with research and development specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, identity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.