Description

tert-Butyl (5-Bromo-1H-Indol-3-Yl)Methylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a brominated indole core protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery and development of new therapeutic agents, particularly in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Kinase Inhibitor Synthesis: Precursor in the creation of bromo-indole based kinase inhibitors for cancer therapy.
• Peptidomimetic Chemistry: Incorporated into peptide analogs to enhance stability and bioavailability.
• Chemical Biology Probes: Used to develop tool compounds for studying biological processes and target validation.

Basic Information

Product Name	tert-Butyl (5-Bromo-1H-Indol-3-Yl)Methylcarbamate
CAS No.	339282-64-3
Molecular Formula	C₁₄H₁₇BrN₂O₂
Molecular Weight	325.20 g/mol
Synonyms	5-Bromo-3-((tert-butoxycarbonyl)(methyl)amino)-1H-indole; tert-Butyl N-[(5-bromo-1H-indol-3-yl)methyl]-N-methylcarbamate; 5-Bromo-1H-indole-3-carboxylic acid, N-methyl-N-[(1,1-dimethylethoxy)carbonyl]methylamide; Boc-5-Bromo-3-(N-methylaminomethyl)indole; (5-Bromo-1H-indol-3-yl)methyl(methyl)carbamic acid tert-butyl ester; 339282-64-3; tert-Butyl (5-bromo-1H-indol-3-yl)methyl(methyl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl (5-Bromo-1H-Indol-3-Yl)Methylcarbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.