Description

Thieno[2,3-C]Pyridine-3-Carboxylic Acid, 2-Amino-6-[5,7-Bis(Trifluoromethyl)-1,8-Naphthyridin-2-Yl]-4,5,6,7-Tetrahydro-, Methyl Ester (9Ci) is a sophisticated heterocyclic organic compound featuring a fused thienopyridine core linked to a bis(trifluoromethyl)-substituted naphthyridine moiety. This complex molecular architecture makes it a highly valuable intermediate for advanced research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, especially in areas requiring complex, fluorinated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique fused-ring system and fluorine atoms.
• Chemical Biology Probe Development: Serves as a precursor for creating specialized molecular probes to study biological pathways and enzyme functions.
• Advanced Material Synthesis: Potential intermediate for developing organic electronic materials or specialty ligands for catalysis, leveraging its electron-deficient aromatic system.
• Contract Research & Development (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for pioneering studies in organic synthesis methodology and heterocyclic chemistry.

Basic Information

Product Name	Thieno[2,3-C]Pyridine-3-Carboxylic Acid, 2-Amino-6-[5,7-Bis(Trifluoromethyl)-1,8-Naphthyridin-2-Yl]-4,5,6,7-Tetrahydro-, Methyl Ester (9Ci)
CAS No.	339096-58-1
Molecular Formula	C₂₀H₁₄F₆N₄O₂S
Molecular Weight	488.41 g/mol
Synonyms	2-Amino-6-[5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid methyl ester; Methyl 2-amino-6-(5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate; 339096-58-1; Thienopyridine-naphthyridine derivative; Bis(trifluoromethyl)naphthyridinyl tetrahydrothienopyridine carboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and LC-MS to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment. We support our partners in the pharmaceutical supply chain with the necessary documentation for their regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.