Description

1-[(tert-Butoxy)Carbonyl]-2,3-Dihydro-1H-Indole-5-Carboxylic Acid is a high-purity, protected indole derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring a versatile intermediate with a reactive carboxylic acid group and a Boc-protected secondary amine, enabling selective deprotection and further functionalization. It is primarily utilized in the pharmaceutical and agrochemical industries for the development of novel active ingredients, including kinase inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Agrochemical Synthesis: Used in the development of new-generation pesticides and herbicides, leveraging the indole scaffold's bioactivity.
• Peptidomimetics & PROTACs: Serves as a crucial component in the design of peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) for targeted protein degradation.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying enzyme function and protein-protein interactions.
• Material Science Research: Acts as a precursor for functionalized polymers and advanced organic materials with specific electronic properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects and scale-up development.

Basic Information

Product Name	1-[(tert-Butoxy)Carbonyl]-2,3-Dihydro-1H-Indole-5-Carboxylic Acid
CAS No.	339007-88-4
Molecular Formula	C14H17NO4
Molecular Weight	263.29 g/mol
Synonyms	5-Carboxy-2,3-dihydro-1H-indole-1-carboxylic acid tert-butyl ester; 1-Boc-2,3-dihydro-1H-indole-5-carboxylic acid; 1-N-Boc-2,3-dihydroindole-5-carboxylic acid; tert-Butyl 5-carboxy-2,3-dihydro-1H-indole-1-carboxylate; Boc-Dihydroindole-5-carboxylic Acid; 1-(tert-Butoxycarbonyl)-2,3-dihydro-1H-indole-5-carboxylic acid; 1-Boc-indoline-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 1-[(tert-Butoxy)Carbonyl]-2,3-Dihydro-1H-Indole-5-Carboxylic Acid adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity. All material is subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.