Description

3α,7α-Dihydroxycoprostanic Acid-D3 is a deuterium-labeled analog of a key bile acid intermediate. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and precision in analytical measurements. It is primarily required by pharmaceutical R&D laboratories, clinical diagnostic facilities, and academic research institutions focused on lipid metabolism, hepatology, and biomarker discovery.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of endogenous bile acids and related metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in tracing metabolic pathways and evaluating the pharmacokinetic profiles of drug candidates affecting cholesterol or bile acid synthesis.
• Clinical Diagnostics: Enables precise measurement of bile acid profiles for diagnosing and monitoring liver diseases, cholestasis, and inborn errors of metabolism.
• Biomarker Research: Facilitates discovery and validation of bile acid signatures as potential biomarkers for various gastrointestinal and metabolic disorders.
• Stable Isotope Dilution Analysis (SIDA): Serves as the reference compound in this gold-standard method for achieving traceable and reliable quantitative results.
• Synthesis of Labeled Metabolites: Acts as a key synthetic precursor for preparing other deuterium-labeled metabolites for advanced research applications.

Basic Information

Product Name	3α,7α-Dihydroxycoprostanic Acid-D3
CAS No.	338976-76-4
Molecular Formula	C27H43D3O4
Molecular Weight	~437.66 g/mol
Synonyms	(25R)-3α,7α-Dihydroxy-5β-cholestan-26-oic-26,26,26-d3 acid; 3α,7α-Dihydroxy-5β-cholestanoic-26,26,26-d3 acid; 5β-Cholestanoic-26,26,26-d3 acid, 3α,7α-dihydroxy-; DHCA-d3; Deuterated Dihydroxycoprostanic Acid; [26,26,26-2H3]-3α,7α-Dihydroxy-5β-cholestanoic Acid
EINECS	Contact for details

Quality Control

Every batch of 3α,7α-Dihydroxycoprostanic Acid-D3 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical purity and MS for isotopic enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformity to your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 97%
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.