Description

3-[(4-Chloroanilino)Methylene]-1,6,7,11B-Tetrahydro-2H-Pyrido[2,1-A]Isoquinoline-2,4(3H)-Dione is a sophisticated heterocyclic organic compound with a complex fused-ring structure, serving as a critical advanced pharmaceutical intermediate in modern synthetic chemistry. Its unique molecular architecture makes it a valuable building block for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex nitrogen-containing scaffolds. This high-purity intermediate is essential for pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex molecules for medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing complex polycyclic structures.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) in academic and industrial research settings.
• Organic Synthesis Building Block: Employed in advanced organic synthesis to construct complex fused-ring systems, leveraging its reactive methylene and carbonyl groups for further functionalization.
• Fine Chemical Production: Serves as a high-value intermediate in the contract manufacturing of specialty chemicals and custom synthesis projects for the life sciences industry.
• Biochemical Research: Potential use in the development of chemical probes or inhibitors for studying biological pathways involving specific enzyme or receptor interactions.

Basic Information

Product Name	3-[(4-Chloroanilino)Methylene]-1,6,7,11B-Tetrahydro-2H-Pyrido[2,1-A]Isoquinoline-2,4(3H)-Dione
CAS No.	338953-30-3
Molecular Formula	C20H16ClN3O2
Molecular Weight	365.81 g/mol
Synonyms	3-[(4-Chloroanilino)methylene]-1,6,7,11b-tetrahydro-2H-pyrido[2,1-a]isoquinoline-2,4(3H)-dione; 3-[(4-Chlorophenylamino)methylene]-1,6,7,11b-tetrahydro-2H-pyrido[2,1-a]isoquinoline-2,4(3H)-dione; 338953-30-3; Pyrido[2,1-a]isoquinoline-2,4(3H)-dione, 3-[(4-chloroanilino)methylene]-1,6,7,11b-tetrahydro-; 3-((4-Chloroanilino)methylene)-1,6,7,11b-tetrahydro-2H-pyrido[2,1-a]isoquinoline-2,4(3H)-dione
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS). We provide full traceability and detailed Certificates of Analysis (COA) upon request, which document all critical quality attributes. Our commitment to quality supports its use in cGMP-compliant pharmaceutical development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.