Description

3-Thiophenecarbonitrile, 2-Amino-5-Chloro- is a high-purity, heterocyclic organic building block of significant importance in advanced chemical synthesis. This compound matters as a key intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific thiophene-based functionalities into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the thiophene moiety contributes to biological activity.
• Material Science Research: Acts as a building block for creating functionalized polymers, organic semiconductors, and conductive materials for electronic applications.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions and other catalytic processes.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments for high-performance coatings and imaging technologies.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules on a commercial scale.

Basic Information

Product Name	3-Thiophenecarbonitrile, 2-Amino-5-Chloro-
CAS No.	338740-31-1
Molecular Formula	C5H3ClN2S
Molecular Weight	158.61 g/mol
Synonyms	2-Amino-5-chlorothiophene-3-carbonitrile; 5-Chloro-2-aminothiophene-3-carbonitrile; 5-Chloro-2-amino-3-cyanothiophene; 2-Amino-5-chloro-3-thiophenecarbonitrile; 3-Cyano-5-chloro-2-aminothiophene; 5-Chloro-2-aminothiophene-3-carbonitrile; 2-Amino-5-chloro-thiophene-3-carbonitrile; 338740-31-1
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-5-chlorothiophene-3-carbonitrile is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with comprehensive control of related substances and residual solvents. Certificates of Analysis (COA) detailing the results of identity (IR, NMR), assay (HPLC), and impurity profile are available upon request for full traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.