Description

5-Hydroxymethylthiophene-2-Boronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. This compound matters for its dual functionality, featuring both a boronic acid group for Suzuki-Miyaura cross-coupling reactions and a hydroxymethyl group for further derivatization, enabling the efficient construction of complex thiophene-containing molecules. It is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and materials science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing thiophene heterocycles for various therapeutic areas.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the thiophene moiety imparts specific biological activity.
• Material Science & OLED Development: Serves as a precursor for constructing conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs) and electronic materials.
• Ligand & Catalyst Preparation: The boronic acid group allows for integration into complex ligands used in catalysis and molecular recognition systems.
• Chemical Biology & Probe Development: Utilized in synthesizing molecular probes and bioconjugates for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CROs/CMOs serving the global chemical industry.

Basic Information

Product Name	5-Hydroxymethylthiophene-2-Boronic Acid
CAS No.	338454-45-8
Molecular Formula	C5H7BO3S
Molecular Weight	157.98 g/mol
Synonyms	(5-Hydroxymethylthiophen-2-yl)boronic Acid; 2-Borono-5-hydroxymethylthiophene; 5-(Hydroxymethyl)thiophene-2-boronic Acid; 5-Hydroxymethyl-2-thienylboronic Acid; Thiophene-2-boronic acid, 5-(hydroxymethyl)-; 5-Hydroxymethylthiophene-2-boronic Acid Pinacol Ester (common derivative); 5-(Hydroxymethyl)-2-thiopheneboronic Acid
EINECS	Contact for details

Quality Control

Our 5-Hydroxymethylthiophene-2-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical: 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.