Description

7-(2-Hydroxy-3-(o-Tolyloxy)Propyl)-3-Methyl-8-(Propylthio)-3,7-Dihydro-1H-Purine-2,6-Dione is a high-purity, advanced pharmaceutical intermediate with a complex purine-dione core structure. This compound matters for its role as a critical building block in the synthesis of novel therapeutic agents, particularly those targeting adenosine receptor pathways. Pharmaceutical R&D and fine chemical manufacturers need this material for developing next-generation drugs, where its precise chemical architecture enables specific biological activity.

Application

• Pharmaceutical Intermediate: Primary use as a key synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Adenosine Receptor Ligand Synthesis: Core structure for creating potent and selective antagonists or agonists for A1, A2A, A2B, and A3 receptor subtypes.
• Cardiovascular & Neuroprotective Agent Research: Used in preclinical studies for compounds intended to treat conditions like ischemia, inflammation, and neurodegenerative diseases.
• Chemical Biology Probe Development: Serves as a scaffold for creating tool compounds to study purinergic signaling pathways in vitro and in vivo.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of target drug candidates.
• Reference Standard: High-purity material suitable for use as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	7-(2-Hydroxy-3-(o-Tolyloxy)Propyl)-3-Methyl-8-(Propylthio)-3,7-Dihydro-1H-Purine-2,6-Dione
CAS No.	332103-51-2
Molecular Formula	C19H24N4O4S
Molecular Weight	404.48 g/mol
Synonyms	3-Methyl-8-(propylthio)-7-[2-hydroxy-3-(2-methylphenoxy)propyl]-3,7-dihydro-1H-purine-2,6-dione; 8-(Propylthio)-3-methyl-7-[2-hydroxy-3-(o-tolyloxy)propyl]-3,7-dihydro-1H-purine-2,6-dione; PSB-1115; Adenosine A2B Receptor Antagonist PSB-1115; 1H-Purine-2,6-dione, 3,7-dihydro-7-[2-hydroxy-3-(2-methylphenoxy)propyl]-3-methyl-8-(propylthio)-; o-Tolyloxypropyl Purinedione Derivative
EINECS	Contact for details

Quality Control

Our 7-(2-Hydroxy-3-(o-Tolyloxy)Propyl)-3-Methyl-8-(Propylthio)-3,7-Dihydro-1H-Purine-2,6-Dione is manufactured under strict GMP-like conditions to ensure batch-to-batch consistency and traceability. All products undergo rigorous quality testing including HPLC purity, identity confirmation (IR, NMR), and residual solvent analysis to meet the stringent requirements of pharmaceutical development. Comprehensive Certificates of Analysis (COA) are provided with each shipment, detailing all specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere (e.g., nitrogen or argon) in a sealed container. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.