Description

Boc-(R)-2-Tetrahydroisoquinoline Acetic Acid is a high-purity, chiral building block essential for advanced organic synthesis. This compound matters because it provides a protected amine functionality and a stereogenic center, enabling the precise construction of complex molecules. It is primarily needed by pharmaceutical and biotechnology R&D teams for the development of active pharmaceutical ingredients (APIs), peptide mimetics, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of drug candidates targeting neurological and cardiovascular diseases.
• Peptidomimetic Chemistry: Used to introduce constrained, non-natural amino acid motifs into peptide backbones to enhance stability and bioavailability.
• Asymmetric Synthesis: Serves as a versatile starting material or auxiliary in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic agents.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds at various scales.

Basic Information

Product Name	Boc-(R)-2-Tetrahydroisoquinoline Acetic Acid
CAS No.	332064-64-9
Molecular Formula	C₁₆H₂₁NO₄
Molecular Weight	291.34 g/mol
Synonyms	(R)-2-(1-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-2-yl)acetic Acid; (R)-2-(1-Boc-1,2,3,4-tetrahydroisoquinolin-2-yl)acetic Acid; (R)-N-Boc-1,2,3,4-Tetrahydroisoquinoline-2-acetic Acid; Boc-Tic-OH (R-isomer); (R)-Boc-Tic-OH; (R)-2-(1,2,3,4-Tetrahydro-1-isoquinolinyl)acetic Acid N-Boc Derivative; (R)-N-tert-Butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline-2-acetic Acid
EINECS	Contact for details

Quality Control

Our Boc-(R)-2-Tetrahydroisoquinoline Acetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP guidelines where applicable, and specifications can be tailored to meet specific project requirements from research to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.