Description

(S)-2-Tetrahydroisoquinoline Acetic Acid-Hcl CAS NO 332062-12-1 is a high-purity chiral intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key building block for constructing complex molecules with specific stereochemistry, which is critical for biological activity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular research.
• Agrochemical Synthesis: Used in the development of advanced, stereospecific pesticides and herbicides where the (S)-enantiomer confers specific biological activity.
• Asymmetric Catalysis Research: Serves as a ligand precursor or a chiral auxiliary in the development of new catalytic systems for enantioselective reactions.
• Peptidomimetics Development: Incorporated into the backbone of peptide-like molecules to enhance stability and bioavailability for therapeutic applications.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in medicinal chemistry and synthetic methodology projects.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals beyond pharmaceuticals.

Basic Information

Product Name	(S)-2-Tetrahydroisoquinoline Acetic Acid Hydrochloride
CAS No.	332062-12-1
Molecular Formula	C₁₁H₁₃NO₂·HCl
Molecular Weight	227.69 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydroisoquinoline-2-acetic acid hydrochloride; (S)-Tic-OH·HCl; (S)-2-Carboxymethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; (S)-2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)acetic acid hydrochloride; (S)-2-(1,2,3,4-Tetrahydro-2-isoquinolyl)acetic acid HCl; (S)-TQAA-HCl; (S)-Tetrahydroisoquinoline-2-yl-acetic acid HCl salt
EINECS	Contact for details

Quality Control

Our (S)-2-Tetrahydroisoquinoline Acetic Acid-Hcl is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) standards where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.