Description

2,8,9-Tri-I-Butyl-2,5,8,9-Tetraaza-1-Phosphabicyclo[3.3.3]Undecane is a sophisticated, sterically hindered bicyclic phosphazene base, a key member of the Verkade superbase family. Its exceptional non-nucleophilic basicity and thermal stability make it a powerful tool for demanding deprotonation reactions where conventional organolithium or amide bases fail. This high-performance reagent is essential for researchers and process chemists in advanced organic synthesis, particularly for the development of pharmaceuticals, agrochemicals, and specialty materials.

Application

• Advanced Organic Synthesis: As a potent, non-nucleophilic base for the generation of sensitive carbanions and enolates in C-C bond-forming reactions.
• Pharmaceutical Intermediate Manufacturing: Facilitating challenging deprotonation steps in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Polymer Chemistry & Catalysis: Serving as an initiator or catalyst component in ring-opening polymerizations (ROP) and as a ligand for transition metal catalysts.
• Agrochemical Research: Enabling the synthesis of novel, high-value crop protection agents and pesticide intermediates.
• Materials Science: Used in the development of advanced materials, including liquid crystals, electrolytes, and flame retardants.
• Methodology Development: A critical reagent in academic and industrial R&D for exploring new reaction pathways under mild conditions.

Basic Information

Product Name	2,8,9-Tri-I-Butyl-2,5,8,9-Tetraaza-1-Phosphabicyclo[3.3.3]Undecane
CAS No.	331465-71-5
Molecular Formula	C18H39N4P
Molecular Weight	342.50 g/mol
Synonyms	Verkade's Superbase; 2,8,9-Triisobutyl-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane; TBTP; Triisobutylphosphazene Base; P1(t-Bu) Base; 1-tert-Butyl-4,4,4-tris(dimethylamino)-2,2-bis[tris(dimethylamino)phosphoranylidenamino]-2λ5,4λ5-catenadi(phosphazene)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized by NMR (1H, 13C, 31P) and HPLC analysis to confirm structural identity and high chemical purity. We maintain strict in-process controls and adhere to cGMP principles where applicable. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.