Description

2-Phenoxypyrimidine-5-Boronic Acid Pinacol Ester is a high-value boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific aryl-pyrimidine scaffolds.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs or molecular sensors.
• Cross-Coupling Reactions: Specifically designed as a stable, air-handleable reagent for palladium-catalyzed Suzuki-Miyaura couplings with various aryl/heteroaryl halides.
• Chemical Library Development: Enables the rapid, parallel synthesis of diverse compound libraries for high-throughput screening in drug discovery.
• Ligand and Catalyst Design: Used to synthesize novel bidentate or tridentate ligands for transition metal catalysis.

Basic Information

Product Name	2-Phenoxypyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	330792-85-3
Molecular Formula	C₁₆H₁₉BN₂O₃
Molecular Weight	298.15 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-phenoxypyrimidine; 2-Phenoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-Phenoxypyrimidin-5-ylboronic Acid Pinacol Ester; 5-(2-Phenoxypyrimidin-5-yl)boronic Acid Pinacol Ester; Pinacol 2-Phenoxypyrimidine-5-boronate
EINECS	Contact for details

Quality Control

Our 2-Phenoxypyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.