Description

Ethyl 2-[[2-(1H-Benzimidazol-2-ylsulfanyl)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate is a sophisticated heterocyclic organic compound that serves as a critical advanced intermediate in pharmaceutical research and development. Its complex molecular architecture, featuring fused benzimidazole and cyclopentathiophene rings, makes it a valuable scaffold for synthesizing novel active pharmaceutical ingredients (APIs). This compound is primarily sought by research chemists and process development scientists working in medicinal chemistry, particularly for projects targeting new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates in medicinal chemistry programs.
• Protease Inhibitor Research: Used in the development of potential inhibitors for various protease enzymes, a common target class.
• Kinase Inhibitor Scaffold: Serves as a core structure for designing and synthesizing potential kinase inhibitor molecules.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes to study biological pathways and protein functions.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of target molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	Ethyl 2-[[2-(1H-Benzimidazol-2-ylsulfanyl)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS No.	330555-46-9
Molecular Formula	C19H19N3O3S2
Molecular Weight	401.50 g/mol
Synonyms	Ethyl 2-[[2-(1H-benzimidazol-2-ylthio)acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate; 2-[[2-(1H-Benzimidazol-2-ylsulfanyl)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid ethyl ester; Ethyl 2-({2-[(1H-benzimidazol-2-yl)sulfanyl]acetyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate; 330555-46-9; Benzimidazole-thiophene carboxylate derivative
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles, ensuring traceability and consistency for your critical R&D and scale-up work. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) compliance for pharmaceutical applications, and specifications can be aligned with client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any individual impurity ≤ 1.0% Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.