Description

3-Acetylamino-5-Fluoro-1H-Indole-2-Carboxylic Acid is a high-purity, fluorinated indole derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a carboxylic acid and an acetamido group on the indole core, makes it a versatile intermediate for constructing complex pharmacologically active molecules. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Biochemical Research: Serves as a precursor for fluorescent probes or enzyme inhibitors used in proteomics and cellular signaling studies.
• Material Science: Potential building block for specialty polymers or organic electronic materials due to its conjugated indole system.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Item	Details
Product Name	3-Acetylamino-5-Fluoro-1H-Indole-2-Carboxylic Acid
CAS No.	330439-67-3
Molecular Formula	C11H9FN2O3
Molecular Weight	236.20 g/mol
Synonyms	5-Fluoro-3-acetamidoindole-2-carboxylic acid; 3-Acetamido-5-fluoro-1H-indole-2-carboxylic acid; 2-Carboxy-5-fluoro-3-acetamidoindole; 330439-67-3; 5-Fluoro-3-(acetylamino)-1H-indole-2-carboxylic acid; 3-Acetylamino-5-fluoroindole-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 3-Acetylamino-5-Fluoro-1H-Indole-2-Carboxylic Acid adheres to stringent internal quality standards, ensuring batch-to-batch consistency and high purity suitable for research and development. Each lot is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development projects requiring material produced under GMP-like controls for non-clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.