Description

Ethyl 2-(4-(2,5-Dioxopyrrolidin-1-yl)benzamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS number 330201-00-8. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), valued for its specific molecular architecture that enables targeted drug development. It is essential for research and manufacturing organizations in the pharmaceutical and biotechnology sectors focused on creating novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a specialized linker or warhead component in the design of targeted protein degradation molecules.
• Bioconjugation Chemistry: Utilized in the development of antibody-drug conjugates (ADCs) and other targeted delivery systems due to its reactive succinimide ester moiety.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Chemical Biology Probes: Used to create tools for studying enzyme function and protein interactions within biological systems.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	Ethyl 2-(4-(2,5-Dioxopyrrolidin-1-yl)benzamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS No.	330201-00-8
Molecular Formula	C23H22N2O5S
Molecular Weight	438.50 g/mol
Synonyms	Ethyl 2-[[4-(2,5-dioxo-1-pyrrolidinyl)benzoyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate; 2-[[4-(2,5-Dioxo-1-pyrrolidinyl)benzoyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic Acid Ethyl Ester; 330201-00-8; 4-(2,5-Dioxopyrrolidin-1-yl)-N-[3-(ethoxycarbonyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl]benzamide; N-[3-(Ethoxycarbonyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl]-4-(2,5-dioxo-1-pyrrolidinyl)benzamide
EINECS	Contact for details

Quality Control

Our production of Ethyl 2-(4-(2,5-Dioxopyrrolidin-1-yl)benzamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. All material is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated analytical methods including HPLC, NMR, and MS. We operate in compliance with cGMP guidelines where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged procedures to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.