Description

1-(Thiophene-2-Sulfonyl)-Piperidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique heterocyclic sulfonamide structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel small molecule therapeutics. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas requiring complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug discovery programs.
• Protease Inhibitor Development: The piperidine-3-carboxylic acid sulfonamide moiety is valuable in designing inhibitors for various enzymatic targets.
• Chemical Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) campaigns.
• Academic Research: Serves as a specialized reagent in university and institutional labs studying heterocyclic chemistry and sulfonamide derivatives.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Product Name	1-(Thiophene-2-Sulfonyl)-Piperidine-3-Carboxylic Acid
CAS No.	329909-94-6
Molecular Formula	C10H13NO4S2
Molecular Weight	275.34 g/mol
Synonyms	3-Piperidinecarboxylic acid, 1-(2-thienylsulfonyl)-; 1-(Thiophen-2-ylsulfonyl)piperidine-3-carboxylic acid; 1-(2-Thienylsulfonyl)piperidine-3-carboxylic acid; Piperidine-3-carboxylic acid, 1-(thiophene-2-sulfonyl)-; 1-(Thiophene-2-sulfonyl)piperidine-3-carboxylic acid; 329909-94-6; 1-(2-Thiophenesulfonyl)piperidine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(Thiophene-2-Sulfonyl)-Piperidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.