Description

Ethyl 2-(3-Phenylpropanamido)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is primarily sought by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in innovative drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of proprietary drug candidates, especially in neurological and psychiatric therapeutic areas.
• Organic Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities with tetrahydrobenzo[b]thiophene cores.
• Research & Development (R&D): Essential for academic and industrial research focused on heterocyclic chemistry and the exploration of new pharmacophores.
• Process Chemistry Optimization: Serves as a standard or reference material for scaling up and validating synthetic routes in pilot plants and kilo-labs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials.

Basic Information

Product Name	Ethyl 2-(3-Phenylpropanamido)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxylate
CAS No.	329226-56-4
Molecular Formula	C20H23NO3S
Molecular Weight	357.47 g/mol
Synonyms	Ethyl 2-(3-phenylpropanamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate; 4,5,6,7-Tetrahydro-2-[[(3-phenyl-1-oxopropyl)amino]-benzo[b]thiophene-3-carboxylic acid ethyl ester; 3-Carbethoxy-2-(3-phenylpropionamido)-4,5,6,7-tetrahydrobenzo[b]thiophene; 329226-56-4; Benzo[b]thiophene-3-carboxylic acid, 4,5,6,7-tetrahydro-2-[[3-phenyl-1-oxopropyl]amino]-, ethyl ester
EINECS	Contact for details

Quality Control

Our production of Ethyl 2-(3-Phenylpropanamido)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxylate adheres to stringent quality management protocols. Each batch is analytically verified using advanced techniques including HPLC, GC, and NMR to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality system is designed to support both research and cGMP-grade requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.