Description

2-Amino-n-(4-Methylphenyl)-5,6-Dihydro-4H-Cyclopenta[B]Thiophene-3-Carboxamide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the field of kinase inhibition. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of targeted small-molecule drugs. The material's specific molecular architecture makes it a valuable building block for creating compounds with potential activity in oncology and inflammatory disease pathways.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel kinase inhibitors for oncology and anti-inflammatory applications.
• Chemical Research & Development: Used as a core scaffold in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step synthesis of potential candidate drugs targeting specific enzymatic pathways.
• Biochemical Research: Utilized as a tool compound in biochemical assays to study protein-ligand interactions and enzyme inhibition mechanisms.
• Fine Chemical Manufacturing: Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis and scale-up projects.

Basic Information

Product Name	2-Amino-n-(4-Methylphenyl)-5,6-Dihydro-4H-Cyclopenta[B]Thiophene-3-Carboxamide
CAS No.	329066-87-7
Molecular Formula	C15H16N2OS
Molecular Weight	272.37 g/mol
Synonyms	2-Amino-N-(p-tolyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide; 2-Amino-N-(4-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide; 4,5,6,7-Tetrahydro-2-amino-N-(4-methylphenyl)benzo[b]thiophene-3-carboxamide; Cyclopenta[b]thiophene-3-carboxamide, 2-amino-N-(4-methylphenyl)-5,6-dihydro-4H-; CAS 329066-87-7
EINECS	Contact for details

Quality Control

Our 2-Amino-n-(4-Methylphenyl)-5,6-Dihydro-4H-Cyclopenta[B]Thiophene-3-Carboxamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Specifications can be tailored to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.