Description

[2-(Thiophene-2-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinolin-1-Yl]-Acetic Acid CAS NO 327971-33-5 is a high-purity, advanced pharmaceutical intermediate characterized by its unique molecular architecture combining tetrahydroisoquinoline and thiophene sulfonyl moieties. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel therapeutic agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new chemical entities, particularly for central nervous system (CNS) and metabolic disorder targets.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization programs to develop new bioactive molecules.
• Biochemical Tool Compound: Employed in biochemical assays and as a reference standard for analytical method development in drug discovery pipelines.
• Contract Research & Manufacturing (CRAM): Supplied to organizations offering custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	[2-(Thiophene-2-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinolin-1-Yl]-Acetic Acid
CAS No.	327971-33-5
Molecular Formula	C₁₅H₁₅NO₄S₂
Molecular Weight	337.41 g/mol
Synonyms	2-[(2-Thiophenesulfonyl)-1,2,3,4-tetrahydro-1-isoquinolinyl]acetic Acid; 2-[(2-Thienylsulfonyl)-1,2,3,4-tetrahydro-1-isoquinolyl]acetic Acid; 2-((2-(Thiophene-2-sulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetic Acid; (2-(Thiophene-2-sulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetic Acid; 327971-33-5; Acetic acid, 2-[(2-thienylsulfonyl)-1,2,3,4-tetrahydro-1-isoquinolyl]-
EINECS	Contact for details

Quality Control

Our [2-(Thiophene-2-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinolin-1-Yl]-Acetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with complete batch-specific data are provided to guarantee traceability, consistency, and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is stable under these conditions but should be kept away from strong acids and organic solvents as indicated by its chemical properties. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.