Description

1-(Thiophene-2-Sulfonyl)-Piperidine-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a distinct heterocyclic structure. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring complex sulfonamide and piperidine motifs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Sulfonamide-Based API Synthesis: Serves as a key starting material for the development of APIs containing the thiophene-sulfonyl pharmacophore.
• Protease Inhibitor Development: Potential building block for the creation of enzyme inhibitors, leveraging its carboxylic acid and sulfonamide functional groups.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale GMP batches.
• Academic & Institutional Research: Used in university and institutional labs for fundamental research in organic synthesis and bioorganic chemistry.

Basic Information

Product Name	1-(Thiophene-2-Sulfonyl)-Piperidine-4-Carboxylic Acid
CAS No.	327971-19-7
Molecular Formula	C10H13NO4S2
Molecular Weight	275.34 g/mol
Synonyms	4-Piperidinecarboxylic acid, 1-(2-thienylsulfonyl)-; 1-(Thiophen-2-ylsulfonyl)piperidine-4-carboxylic acid; Piperidine-4-carboxylic acid, 1-(thiophene-2-sulfonyl)-; 1-(2-Thienylsulfonyl)-4-piperidinecarboxylic Acid; 327971-19-7; 1-(Thiophene-2-sulfonyl)piperidine-4-carboxylic acid; 1-(Thiophene-2-sulphonyl)piperidine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(Thiophene-2-Sulfonyl)-Piperidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.