Description

1-Palmitoyl(D31)-2-Oleoyl-Sn-Glycero-3-[Phospho-Rac-(1-Glycerol)] (Sodium Salt) is a high-purity, deuterium-labeled phospholipid, specifically a sodium salt of POPG (1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)). This compound is an essential tool for advanced research, providing a stable isotopic label for precise tracking and quantification in complex biological systems. It is primarily utilized by researchers in the fields of lipidomics, membrane biophysics, and metabolic pathway analysis who require the highest standards of isotopic purity and structural integrity.

Application

• Biophysical Research: As a deuterated standard for studying phospholipid bilayer dynamics, membrane fluidity, and protein-lipid interactions using techniques like NMR spectroscopy and neutron scattering.
• Quantitative Lipidomics: Serving as a critical internal standard for the accurate mass spectrometry-based quantification of phosphatidylglycerol (PG) species in complex biological samples such as cell lysates, plasma, and tissue extracts.
• Metabolic Tracing: Enabling detailed investigation of phospholipid synthesis, remodeling, and turnover pathways in cellular and in vivo models.
• Pharmaceutical Development: Used in the research and development of lipid-based drug delivery systems, including liposomes and lipid nanoparticles (LNPs), where understanding lipid behavior is crucial.
• Diagnostic Assay Development: Acting as a calibrant or reference material in clinical research assays targeting phospholipid biomarkers.
• Quality Control: Providing a certified reference material for ensuring the accuracy and precision of analytical methods in contract research organizations (CROs) and quality control laboratories.

Basic Information

Product Name	1-Palmitoyl(D31)-2-Oleoyl-Sn-Glycero-3-[Phospho-Rac-(1-Glycerol)] (Sodium Salt)
CAS No.	327178-87-0
Molecular Formula	C41H48D31NaO10P
Molecular Weight	~809.3 g/mol (for major isotopologue)
Synonyms	POPG-d31 (Sodium Salt); 1-Palmitoyl-d31-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (Sodium Salt); Deuterated POPG; Sodium 1-(hexadecanoyl-d31)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-rac-glycerol); PG(16:0-d31/18:1(9Z)) Sodium Salt; Phosphatidylglycerol-d31 (16:0/18:1); (Rac)-PG-d31 Sodium Salt; 1-Palmitoyl(d31)-2-oleoyl-phosphatidylglycerol Sodium Salt
EINECS	Contact for details

Quality Control

Every batch of our deuterated phospholipids is produced and analyzed under strict quality control protocols to ensure exceptional isotopic and chemical purity, critical for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) that include data from NMR, HPLC, and mass spectrometry. Our manufacturing process adheres to cGMP principles where applicable, supporting traceability and consistency for our global research and pharmaceutical clients.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98% (by area)
Isotopic Enrichment	≥ 98 atom % D (by MS)
Chemical Purity (TLC)	Single spot
Solubility	Soluble in chloroform, methanol, ethanol
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.