Description

Benzyl 6-Amino-5,7,7-Tricyano-8-(3,4-Difluorophenyl)-3,7,8,8A-Tetrahydroisoquinoline-2(1H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex, multi-functional heterocyclic structure. This compound is of significant commercial value for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical sectors engaged in developing new drug candidates.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a critical building block for the development of novel small-molecule drug candidates.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes.
• Precursor for Complex Heterocycles: Its reactive functional groups (amino, cyano, carboxylate) make it a versatile precursor for constructing more complex nitrogen-containing heterocyclic systems.
• Targeted Therapeutic Areas: Potential applications in the research of central nervous system (CNS) agents, oncology therapeutics, or anti-infectives due to its structural features.
• Process Chemistry Scale-up: Supplied for process development and optimization from laboratory to pilot plant scale.
• Custom Synthesis Starting Material: Utilized by fine chemical companies for the custom synthesis of specialized compounds for client projects.

Basic Information

Item	Details
Product Name	Benzyl 6-Amino-5,7,7-Tricyano-8-(3,4-Difluorophenyl)-3,7,8,8A-Tetrahydroisoquinoline-2(1H)-Carboxylate
CAS No.	327068-38-2
Molecular Formula	C27H19F2N5O2
Molecular Weight	483.47 g/mol
Synonyms	Benzyl 6-amino-5,7,7-tricyano-8-(3,4-difluorophenyl)-1,2,3,7,8,8a-hexahydroisoquinoline-2-carboxylate; 327068-38-2; 6-Amino-5,7,7-tricyano-8-(3,4-difluorophenyl)-3,7,8,8a-tetrahydro-1H-isoquinoline-2-carboxylic acid benzyl ester; 8-(3,4-Difluorophenyl)-6-amino-5,7,7-tricyano-3,7,8,8a-tetrahydro-1H-isoquinoline-2-carboxylic acid benzyl ester
EINECS	Contact for details

Quality Control

Our Benzyl 6-Amino-5,7,7-Tricyano-8-(3,4-Difluorophenyl)-3,7,8,8A-Tetrahydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.