Description

1,2-Dimyristoyl-D54-Sn-Glycero-3-[Phospho-Rac-(1-Glycerol)] (Sodium Salt) is a deuterated, saturated phospholipid with a defined 14-carbon (myristoyl) fatty acid chain, serving as a critical structural and functional analog in advanced research. This compound matters for its role as a stable, non-radioactive isotopic tracer, enabling precise investigation of lipid metabolism, membrane dynamics, and protein-lipid interactions without interfering with biological systems. It is essential for researchers and developers in biophysics, structural biology, and pharmaceutical R&D, particularly for NMR spectroscopy, mass spectrometry, and the formulation of model membrane systems like liposomes and bicelles.

Application

• NMR Spectroscopy & Structural Biology: As a deuterium-labeled lipid for probing membrane protein structure, dynamics, and orientation within lipid bilayers using solid-state NMR techniques.
• Mass Spectrometry & Lipidomics: Utilized as a stable isotope-labeled internal standard for the accurate quantification of phosphatidylglycerol (PG) lipids in complex biological samples.
• Model Membrane Systems: A key component for constructing defined, stable liposomes, vesicles, and bicelles used in biophysical studies of membrane permeability, fusion, and protein insertion.
• Drug Delivery Research: Incorporated into lipid nanoparticle (LNP) formulations and liposomal drug carriers to study encapsulation efficiency, release kinetics, and in vivo distribution using tracer methodologies.
• Metabolic Pathway Tracing: Employed in deuterium tracing studies to map the biosynthesis and turnover pathways of phospholipids in cellular and microbiological systems.
• Surface Chemistry & Biosensors: Used to create supported lipid bilayers (SLBs) with tailored properties for sensor development and studying cell-surface interactions.

Basic Information

Product Name	1,2-Dimyristoyl-D54-Sn-Glycero-3-[Phospho-Rac-(1-Glycerol)] (Sodium Salt)
CAS No.	326495-45-8
Molecular Formula	C36D54H17NaO10P
Molecular Weight	~ 724.8 g/mol (deuterated form)
Synonyms	1,2-Dimyristoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (Sodium Salt) (deuterated); DMPG-d54 (Sodium Salt); 1,2-Dimyristoylphosphatidylglycerol-d54 (Sodium Salt); 14:0 PG-d54 (Sodium Salt); Deuterated DMPG (Sodium Salt); 1,2-Ditetradecanoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (Sodium Salt)-d54; PG(14:0/14:0)-d54 (Sodium Salt); (Rac)-1,2-Dimyristoyl-3-phosphatidylglycerol-d54 (Sodium Salt)
EINECS	Contact for details

Quality Control

Our deuterated phospholipids are produced and analyzed under strict quality protocols to ensure isotopic purity, chemical identity, and batch-to-batch consistency critical for sensitive research applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-incorporation), chemical purity, and specific analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 95% (by area normalization)
Solubility	Soluble in chloroform, methanol, chloroform/methanol mixtures
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.