Description

1-Palmitoyl(D31)-2-Oleoyl-Sn-Glycero-3-Phosphoethanolamine is a high-purity, deuterium-labeled phospholipid, specifically a phosphatidylethanolamine (PE). This compound is a critical tool for advanced analytical research, offering a stable isotopic label for precise tracking and quantification in complex biological systems. It is essential for researchers and scientists in the fields of lipidomics, membrane biophysics, and metabolic pathway analysis who require the highest standards of isotopic purity and structural fidelity for their experiments.

Application

• Internal Standard for Lipidomics: Used as a quantitative internal standard in mass spectrometry (MS) and liquid chromatography-mass spectrometry (LC-MS) for the accurate measurement of endogenous phosphatidylethanolamine species.
• Membrane Biophysics Research: Employed in studies investigating lipid bilayer properties, membrane fluidity, protein-lipid interactions, and raft formation due to its deuterated palmitoyl chain.
• Metabolic Tracing: Serves as a tracer in metabolic flux analysis to study phospholipid synthesis, remodeling, and degradation pathways in cells and model organisms.
• Drug Delivery & Formulation Studies: Utilized in the development and analysis of liposomal and nanoparticle drug delivery systems to track lipid components.
• Biomarker Discovery & Validation: Acts as a reference compound in clinical and preclinical research for identifying and validating lipid-based biomarkers.
• Quality Control in Pharmaceutical Development: Provides a certified reference material for method development and validation in pharmaceutical analysis of lipid-based therapeutics.

Basic Information

Product Name	1-Palmitoyl(D31)-2-Oleoyl-Sn-Glycero-3-Phosphoethanolamine
CAS No.	326495-44-7
Molecular Formula	C39H45D31NO8P
Molecular Weight	~772.3 g/mol (for deuterated form)
Synonyms	POPE-d31; 1-Palmitoyl-d31-2-oleoyl-sn-glycero-3-phosphoethanolamine; Deuterated POPE; (16:0-d31/18:1)-PE; 1-Hexadecanoyl-d31-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; PE(16:0/18:1)-d31; D31-Palmitoyl Oleoyl Phosphatidylethanolamine
EINECS	Contact for details

Quality Control

Our deuterated phospholipids are manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications for isotopic enrichment, chemical purity, and absence of critical impurities. We support compliance with cGMP and ISO 9001 standards for research materials, ensuring traceability and reliability for your most demanding projects.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR & MS)	Conforms to structure
Isotopic Enrichment (Deuterium, D)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 95%
Solubility	Soluble in chloroform, methanol, ethanol; forms liposomes in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.