Description

1,2-Dimyristoyl-D54-Sn-Glycero-3-Phosphoethanolamine is a deuterated phospholipid, specifically a perdeuterated dimyristoylphosphatidylethanolamine (DMPE-d54). This compound is a critical research-grade material where isotopic labeling is required for advanced analytical techniques. It is essential for scientists requiring precise molecular probes with minimal background interference in spectroscopic studies. This high-purity lipid is primarily utilized in biophysical research, membrane studies, and the development of diagnostic assays.

Application

• Membrane Biophysics Research: Used in the construction of model lipid bilayers and vesicles (liposomes) for studying membrane fluidity, phase transitions, and protein-lipid interactions using techniques like NMR and neutron scattering.
• Deuterium NMR Spectroscopy (²H-NMR): Serves as a key probe for investigating molecular dynamics, orientation, and order parameters within lipid membranes due to its perdeuterated acyl chains.
• Neutron Scattering Studies: The significant contrast provided by deuterium atoms makes this lipid invaluable for small-angle neutron scattering (SANS) and reflectometry experiments to elucidate membrane structure.
• Lipidomics & Mass Spectrometry: Acts as a stable isotope-labeled internal standard for the accurate quantification of phosphatidylethanolamine species in complex biological samples via LC-MS/MS.
• Drug Delivery System Development: Incorporated into liposomal formulations to study carrier stability, biodistribution, and release kinetics in preclinical research.
• Surface Chemistry & Biosensors: Used to create supported lipid bilayers (SLBs) on sensor surfaces for studying biomolecular interactions in a controlled membrane environment.

Basic Information

Product Name	1,2-Dimyristoyl-D54-Sn-Glycero-3-Phosphoethanolamine
CAS No.	326495-41-4
Molecular Formula	C33D54NO8P
Molecular Weight	~678.9 g/mol (deuterated form)
Synonyms	DMPE-d54; 1,2-Ditetradecanoyl-D54-sn-glycero-3-phosphoethanolamine; Deuterated DMPE; DMPE-perdeuterated; 1,2-Dimyristoylphosphatidylethanolamine-d54; (2R)-2,3-Bis[(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14-tetracosadeuteriotetradecanoyl)oxy]propyl (2-aminoethyl) hydrogen phosphate; Phosphatidylethanolamine-d54 (14:0/14:0).
EINECS	Contact for details

Quality Control

Our deuterated lipids are produced and handled under strict quality protocols to ensure the highest isotopic and chemical purity for research applications. Each batch is characterized by advanced analytical techniques, including NMR, Mass Spectrometry, and HPLC, to confirm deuteration level, chemical identity, and purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >98 atom % D), chemical purity, and specific analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Deuteration Degree	≥ 98 atom % D
Solubility	Soluble in chloroform, methanol, ethanol; forms liposomes in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.