Description

1,2-Distearoyl-D70-Sn-Glycero-3-Phosphocholine-1,1,2,2-D4-N,N,n-Trimethyl-D9 is a high-purity, multi-deuterated phospholipid essential for advanced research and development. This compound is specifically engineered for use as a critical internal standard in mass spectrometry-based lipidomics, enabling precise quantification and metabolic tracing. It is primarily required by pharmaceutical researchers, analytical laboratories, and academic institutions conducting lipid metabolism studies, drug discovery, and biomarker validation.

Application

• Quantitative Lipidomics Standard: Serves as a stable isotope-labeled internal standard for the absolute quantification of phosphatidylcholines (PC) in complex biological samples via LC-MS/MS.
• Metabolic Flux Analysis: Used in tracer studies to investigate phospholipid biosynthesis, remodeling, and turnover pathways in cellular and animal models.
• Drug Discovery & Pharmacokinetics: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the distribution and metabolism of lipid-based drug formulations.
• Biomarker Research: Facilitates the accurate measurement of specific phospholipid species as potential disease biomarkers in clinical research.
• Method Development & Validation: Critical for developing, optimizing, and validating robust analytical methods in mass spectrometry laboratories.
• Quality Control in Liposome Production: Can be used as a tracer to monitor the consistency and integrity of synthetic lipid vesicles (liposomes) in formulation development.

Basic Information

Product Name	1,2-Distearoyl-D70-Sn-Glycero-3-Phosphocholine-1,1,2,2-D4-N,N,n-Trimethyl-D9
CAS No.	326495-40-3
Molecular Formula	C47D83NO8P
Molecular Weight	~862.20 g/mol (deuterated form)
Synonyms	DSPC-d83; 1,2-Distearoyl-sn-glycero-3-phosphocholine-d83; Deuterated DSPC; 18:0 PC-d83; 1,2-Di(octadecanoyl-d35)-sn-glycero-3-phosphocholine-(choline-methyl-d9, glycerol-1,1,2,2-d4); Phosphatidylcholine(18:0/18:0)-d83; Lipoid S100-d83 (deuterated analog); Deuterated Phosphatidylcholine
EINECS	Contact for details

Quality Control

Our deuterated phospholipids are manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity for research integrity. Each batch is characterized using advanced analytical techniques including NMR and high-resolution mass spectrometry. Certificates of Analysis (COA) are provided, detailing isotopic enrichment (D%), chemical purity, and analytical data. We support compliance with GMP/GLP requirements for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Isotopic Purity (D%)	≥ 98 atom % D (by MS)
Chemical Purity (HPLC)	≥ 95%
Assay	≥ 95% (by P NMR)
Solubility	Soluble in chloroform, ethanol; forms vesicles in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.