Description

4-(3,4-Dihydro-1H-Isoquinoline-2-Sulfonyl)-Benzoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonyl-bridged heterocyclic structure. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting neurological and cardiovascular therapeutic areas. The product is supplied with full analytical documentation to ensure batch-to-batch consistency for critical synthetic pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly those targeting enzyme inhibition.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and for creating focused libraries for high-throughput screening.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the multi-step synthesis of complex active molecules.
• Biochemical Tool Compound: Employed in biochemical assays to study specific biological pathways and protein interactions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Used in university and institutional labs for exploratory organic synthesis and methodological development.

Basic Information

Product Name	4-(3,4-Dihydro-1H-Isoquinoline-2-Sulfonyl)-Benzoic Acid
CAS No.	325702-76-9
Molecular Formula	C₁₆H₁₃NO₄S
Molecular Weight	315.35 g/mol
Synonyms	4-(1,2,3,4-Tetrahydroisoquinoline-2-sulfonyl)benzoic acid; Benzoic acid, 4-[(3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]-; 4-(3,4-Dihydro-1H-isoquinoline-2-sulfonyl)benzoic acid; 2-(4-Carboxybenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline; 325702-76-9; 4-(1,2,3,4-Tetrahydro-isoquinoline-2-sulfonyl)-benzoic acid
EINECS	Contact for details

Quality Control

Every batch of 4-(3,4-Dihydro-1H-Isoquinoline-2-Sulfonyl)-Benzoic Acid is manufactured under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.