Description

Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-6-Fluoro-, (1S,2R,5S,6S)- (9Ci) is a high-purity, stereochemically defined bicyclic amino acid derivative of significant interest in advanced pharmaceutical research. This compound matters as a sophisticated chiral building block, enabling the synthesis of complex molecules with precise three-dimensional architecture. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the discovery and development of new active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders and other therapeutic areas requiring constrained peptide mimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), especially for CNS-targeting drugs.
• Peptidomimetic Design: Serves as a constrained, non-natural amino acid scaffold for creating stable peptide analogs with enhanced metabolic stability and bioavailability.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical space and optimize drug candidate potency and selectivity.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale synthesis of complex target molecules.
• Ligand Synthesis: Potential building block for creating specialized ligands in catalysis or diagnostic imaging agents.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in organic synthesis and chemical biology.

Basic Information

Product Name	Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-6-Fluoro-, (1S,2R,5S,6S)- (9Ci)
CAS No.	321903-59-7
Molecular Formula	C9H10FNO4
Molecular Weight	215.18 g/mol
Synonyms	(1S,2R,5S,6S)-2-Amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid; (1S,2R,5S,6S)-2-Amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid; 2-Amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, (1S,2R,5S,6S)-; Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-6-fluoro-, (1S,2R,5S,6S)-; Fluorinated constrained bicyclic amino acid; CAS 321903-59-7
EINECS	Contact for details

Quality Control

Our Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-6-Fluoro-, (1S,2R,5S,6S)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and specific test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.