Description

Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-6-Methyl-, (1R,2R,5S,6R)- is a high-purity, stereochemically defined bicyclic amino acid derivative of significant interest in advanced organic synthesis. Its unique constrained structure and functional groups make it a valuable chiral building block for the development of novel pharmaceuticals and bioactive compounds. This product is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate rigid, three-dimensional scaffolds into their molecular designs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease therapeutics.
• Peptidomimetics & Conformationally Restricted Peptides: Used to introduce rigidity into peptide backbones, enhancing metabolic stability and receptor selectivity for drug discovery programs.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and insecticides with potentially improved efficacy and environmental profiles.
• Material Science: A potential monomer for creating novel polymers with specific thermal and mechanical properties.
• Academic & Institutional Research: A valuable tool for studying structure-activity relationships (SAR) and novel chemical transformations in organic chemistry.

Basic Information

Product Name	Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-6-Methyl-, (1R,2R,5S,6R)-
CAS No.	321903-28-0
Molecular Formula	C10H15NO4
Molecular Weight	213.23 g/mol
Synonyms	(1R,2R,5S,6R)-2-Amino-6-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid; (1R,2R,5S,6R)-2-Amino-6-methyl-2,6-bicyclo[3.1.0]hexanedicarboxylic acid; 2-Aza-bicyclo[3.1.0]hexane-3,6-dicarboxylic acid derivative; Bicyclo[3.1.0]hexane amino diacid; Constrained glutamic acid analogue; Rigid proline analogue
EINECS	Contact for details

Quality Control

Our Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-6-Methyl-, (1R,2R,5S,6R)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.