Description

5-Bromo-2-Fluoro-Benzenethiol is a versatile aromatic thiol building block characterized by its bromo and fluoro substituents, which confer unique reactivity and electronic properties. This compound is essential for the synthesis of complex molecules, particularly in the development of pharmaceuticals and advanced materials, where its thiol group serves as a key handle for conjugation and functionalization. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing sulfur-containing heterocycles and as a precursor in metal-catalyzed cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs), especially those containing benzothiophene or other sulfur heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage the bioactivity of the thiol and halogenated aryl structure.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis, useful in fine chemical and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials where the thiol group enables surface modification or polymerization.
• Chemical Biology & Bioconjugation: Acts as a reagent for modifying proteins, peptides, or other biomolecules via thiol-disulfide exchange or Michael addition reactions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring specific, halogenated benzenethiol derivatives.

Basic Information

Product Name	5-Bromo-2-Fluoro-Benzenethiol
CAS No.	321596-25-2
Molecular Formula	C6H4BrFS
Molecular Weight	207.06 g/mol
Synonyms	2-Fluoro-5-bromobenzenethiol; 5-Bromo-2-fluorothiophenol; 2-Fluoro-5-bromothiophenol; 5-Bromo-2-fluorophenyl mercaptan; (5-Bromo-2-fluorophenyl)thiol; Benzenethiol, 5-bromo-2-fluoro-; 321596-25-2
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Fluoro-Benzenethiol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Keep away from strong acids, oxidizing agents, and moisture. The storage area should be cool, dry, and well-ventilated.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.