Description

1-(3-Chloro-2-Thienyl)-3-[4-(Trifluoromethoxy)Anilino]-2-Propen-1-One is a high-value, specialized organic intermediate featuring a unique molecular architecture combining thiophene and aniline motifs with a propenone linker. This compound matters for its role as a critical building block in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its specific structure enables precise molecular tuning. It is primarily needed by research and development teams, as well as process chemists, in the pharmaceutical, agrochemical, and advanced material science industries seeking to develop novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the research and synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing anti-inflammatory activity.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, or insecticides, where the trifluoromethoxy and chlorothienyl groups can contribute to biological activity and environmental stability.
• Material Science: Acts as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, or organic semiconductors for electronic applications.
• Chemical Synthesis: Functions as a versatile Michael acceptor or electrophile in organic synthesis, enabling the construction of complex heterocyclic systems.
• Biochemical Tool Compound: Potential use in biochemical assays and as a probe for studying enzyme inhibition or receptor binding mechanisms in academic and industrial research settings.

Basic Information

Product Name	1-(3-Chloro-2-Thienyl)-3-[4-(Trifluoromethoxy)Anilino]-2-Propen-1-One
CAS No.	321433-55-0
Molecular Formula	C14H9ClF3NO2S
Molecular Weight	347.74 g/mol
Synonyms	1-(3-Chloro-2-thienyl)-3-[4-(trifluoromethoxy)anilino]prop-2-en-1-one; (E)-1-(3-Chlorothiophen-2-yl)-3-(4-(trifluoromethoxy)phenylamino)prop-2-en-1-one; 3-[4-(Trifluoromethoxy)anilino]-1-(3-chloro-2-thienyl)-2-propen-1-one; Chalcone derivative, 3-chloro-2-thienyl, 4-trifluoromethoxyanilino; N-(4-(Trifluoromethoxy)phenyl)-3-(3-chlorothiophen-2-yl)-3-oxoprop-1-en-1-amine; CAS 321433-55-0; Propenone, 1-(3-chloro-2-thienyl)-3-[[4-(trifluoromethoxy)phenyl]amino]-; Enone intermediate 321433-55-0
EINECS	Contact for details

Quality Control

Our 1-(3-Chloro-2-Thienyl)-3-[4-(Trifluoromethoxy)Anilino]-2-Propen-1-One is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area Percent)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.