Description

(R)-Boroser(Obn)-(+)-Pinanediol-Hcl is a high-purity chiral boronic ester derivative, specifically the hydrochloride salt of the pinanediol-protected boroserine compound. This advanced intermediate is critical for enabling precise stereochemical control in complex organic syntheses, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the construction of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of protease inhibitors, enzyme inhibitors, and other active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a sophisticated boron reagent for forming carbon-carbon bonds under mild conditions, essential for constructing complex molecular architectures.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and for the rapid exploration of structure-activity relationships (SAR) in lead optimization programs.
• Asymmetric Synthesis: Provides a chiral auxiliary or template for inducing enantioselectivity in various synthetic transformations.
• Agrochemical Research: Employed in the development of novel, stereochemically-defined herbicides, fungicides, and plant growth regulators.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting cutting-edge research in synthetic methodology and catalysis.

Basic Information

Product Name	(R)-Boroser(Obn)-(+)-Pinanediol-Hcl
CAS No.	319009-76-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-2-((((3aR,4R,6S,7aR)-3a,5,5-Trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)oxy)methyl)-4-(tert-butoxy)-4-oxobutan-1-aminium chloride; (R)-Boroserine(Obn) Pinanediol Ester Hydrochloride; (R)-N-Boc-3-(pinanediolboronyl)alanine hydrochloride; (R)-3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-Boc-alanine hydrochloride (Pinanediol variant); Boron-serine derivative HCl salt
EINECS	Contact for details

Quality Control

Every batch of (R)-Boroser(Obn)-(+)-Pinanediol-Hcl is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for chiral purity and chemical identity. Certificates of Analysis (COA) detailing specific tests such as chiral HPLC purity, NMR identification, and assay are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider storing under an inert gas blanket.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.