Description

6,7-Dimethoxy-3,4-Dihydro-1H-Isoquinoline-2,3-Dicarboxylic Acid 2-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate belonging to the isoquinoline class of compounds. This molecule is of significant commercial interest due to its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of alkaloid-based APIs and investigational new drugs.
• Organic Synthesis Building Block: Used in research and development for constructing complex heterocyclic frameworks due to its reactive ester and dihydroisoquinoline structure.
• Medicinal Chemistry Research: Employed in the discovery and optimization of compounds targeting neurological and cardiovascular pathways.
• Process Chemistry Development: Serves as a standardized starting material for scaling up synthetic routes under cGMP conditions.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical manufacturing.

Basic Information

Product Name	6,7-Dimethoxy-3,4-Dihydro-1H-Isoquinoline-2,3-Dicarboxylic Acid 2-tert-Butyl Ester
CAS No.	317806-26-1
Molecular Formula	C₁₇H₂₁NO₆
Molecular Weight	335.35 g/mol
Synonyms	2-(tert-Butyl) 6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylate; 1H-Isoquinoline-2,3-dicarboxylic acid, 3,4-dihydro-6,7-dimethoxy-, 2-(1,1-dimethylethyl) ester; 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2,3-dicarboxylic Acid 2-tert-Butyl Ester; tert-Butyl 6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate-3-carboxylate; 317806-26-1; 2-tert-Butyl 6,7-dimethoxy-3,4-dihydroisoquinoline-2,3-dicarboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and traceability. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ validated analytical methods, including HPLC and NMR, to confirm chemical structure and meet the exacting standards required for pharmaceutical R&D and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.