Description

4,6-Methano-2,1-Benzisoxazole,4,5,6,7-Tetrahydro-5,5-Dimethyl-,(4R,6R)-(9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound matters for its critical role in the synthesis of complex active pharmaceutical ingredients (APIs), where its specific stereochemistry and rigid fused-ring structure are essential for biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries working on novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of proprietary drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Process Chemistry & Scale-Up: Used in the development and optimization of robust, scalable synthetic routes for API manufacturing under cGMP conditions.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	4,6-Methano-2,1-Benzisoxazole,4,5,6,7-Tetrahydro-5,5-Dimethyl-,(4R,6R)-(9Ci)
CAS No.	315674-66-9
Molecular Formula	C11H15NO
Molecular Weight	177.24 g/mol
Synonyms	(4R,6R)-4,5,6,7-Tetrahydro-5,5-dimethyl-4,6-methano-2,1-benzisoxazole; (4R,6R)-5,5-Dimethyl-4,6-methano-4,5,6,7-tetrahydro-2,1-benzisoxazole; (4R,6R)-5,5-Dimethyl-4,6-methanobenzisoxazole; (4R,6R)-Tetrahydro-5,5-dimethyl-4,6-methano-2,1-benzisoxazole; 4,6-Methano-2,1-benzisoxazole, 4,5,6,7-tetrahydro-5,5-dimethyl-, (4R,6R)-; (4R,6R)-DMBI; (4R,6R)-4,6-Methano-2,1-benzisoxazole derivative
EINECS	Contact for details

Quality Control

Our 4,6-Methano-2,1-Benzisoxazole,4,5,6,7-Tetrahydro-5,5-Dimethyl-,(4R,6R)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess and NMR for structural confirmation, to ensure high chemical and isomeric purity suitable for pharmaceutical R&D. Certificates of Analysis (COA) with full analytical data are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.