Description

1H-Indole-1-Carboxylic Acid, 5-(2-Chloroethyl)-2,3-Dihydro-, 1,1-Dimethylethyl Ester is a high-purity, synthetically valuable indole derivative, serving as a critical protected intermediate in advanced organic synthesis. Its molecular architecture, featuring a chloroethyl side chain and a tert-butyl ester protecting group, makes it indispensable for constructing complex heterocyclic frameworks. This compound is primarily sought after by research institutions and pharmaceutical development teams working on novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel indole-based drug candidates targeting neurological and oncological pathways.
• Agrochemical Research: Used in developing advanced herbicides and plant growth regulators that leverage the indole scaffold.
• Organic Synthesis: Serves as a versatile precursor for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and other functional group transformations.
• Chemical Biology: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research.
• Material Science: Potential monomer or intermediate for creating specialty polymers with unique electronic or photophysical properties.

Basic Information

Product Name	1H-Indole-1-Carboxylic Acid, 5-(2-Chloroethyl)-2,3-Dihydro-, 1,1-Dimethylethyl Ester
CAS No.	314727-60-1
Molecular Formula	C15H18ClNO2
Molecular Weight	279.76 g/mol
Synonyms	tert-Butyl 5-(2-chloroethyl)-2,3-dihydro-1H-indole-1-carboxylate; 5-(2-Chloroethyl)-2,3-dihydro-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-5-(2-chloroethyl)indoline; Boc-5-(2-chloroethyl)indoline; N-Boc-5-(2-chloroethyl)indoline; 5-(2-Chloroethyl)indoline-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of 1H-Indole-1-Carboxylic Acid, 5-(2-Chloroethyl)-2,3-Dihydro-, 1,1-Dimethylethyl Ester adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, and NMR for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider holding under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.