Description

Ethyl 2-[(Trifluoroacetyl)Amino]-5,6-Dihydro-4H-Cyclopenta[B]Thiophene-3-Carboxylate is a high-value, multifunctional heterocyclic building block designed for advanced chemical synthesis. This compound is critical for research and development in pharmaceutical chemistry, serving as a key precursor for creating novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. Its unique structure, featuring a cyclopentathiophene core and a reactive trifluoroacetyl amino group, makes it indispensable for medicinal chemists and process development scientists in the life sciences sector.

Application

This specialized intermediate is engineered for high-value synthesis in regulated industries. Its primary and potential applications include:

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• Process Chemistry Development: Serves as a key starting material (KSM) or advanced intermediate in the scale-up and optimization of API manufacturing processes.
• Agrochemical Synthesis: Potential application in the development of new active ingredients for crop protection products.
• Material Science Research: Exploration into novel organic electronic materials or ligands for catalytic systems due to its electron-rich thiophene moiety.

Basic Information

Product Name	Ethyl 2-[(Trifluoroacetyl)Amino]-5,6-Dihydro-4H-Cyclopenta[B]Thiophene-3-Carboxylate
CAS No.	314282-52-5
Molecular Formula	C12H12F3NO3S
Molecular Weight	307.29 g/mol
Synonyms	Ethyl 2-(trifluoroacetamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate; 2-[(Trifluoroacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid ethyl ester; Ethyl 2-(2,2,2-trifluoroacetamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate; 5,6-Dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid, 2-[(trifluoroacetyl)amino]-, ethyl ester; CAS 314282-52-5; Trifluoroacetamide cyclopentathiophene carboxylate ester
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications. We support development under cGMP guidelines for applications requiring regulatory filing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container must be kept tightly sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.