Description

Methyl 2-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a maleimide-functionalized tetrahydrobenzothiophene core, which is critical for bioconjugation and targeted drug delivery applications. This compound is engineered to serve as a key building block in the synthesis of antibody-drug conjugates (ADCs) and other biopharmaceuticals, enabling precise linkage of cytotoxic payloads to targeting molecules. It is essential for R&D and production teams in the pharmaceutical, biotechnology, and life sciences sectors seeking reliable, high-quality intermediates for next-generation therapeutic development.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload Synthesis: Serves as a critical maleimide-containing intermediate for constructing the linker component that attaches potent cytotoxic drugs to monoclonal antibodies.
• Bioconjugation Reagent: Used to functionalize proteins, peptides, and other biomolecules via thiol-maleimide chemistry for diagnostic and therapeutic applications.
• Pharmaceutical Intermediate: A key raw material in the multi-step synthesis of targeted oncology drugs and other specialized therapeutics.
• Chemical Biology Research: Employed in proteomics and cellular biology studies for labeling and tracking biomolecules.
• Polymer & Material Science: Can be incorporated into functional polymers and smart materials requiring reactive handles for further modification.
• Small Molecule Drug Development: Used as a scaffold or precursor in medicinal chemistry programs exploring novel pharmacophores.

Basic Information

Product Name	Methyl 2-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
CAS No.	314279-09-9
Molecular Formula	C15H15NO4S
Molecular Weight	305.35 g/mol
Synonyms	Methyl 1-(3-(methoxycarbonyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1H-pyrrole-2,5-dione; 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid methyl ester; 1-(3-Methoxycarbonyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)maleimide; Tetrahydrobenzo[b]thiophene maleimide ester; Maleimide-functionalized tetrahydrobenzothiophene carboxylate; ADC linker intermediate 314279-09-9; CAS 314279-09-9
EINECS	Contact for details

Quality Control

Our Methyl 2-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity required for sensitive pharmaceutical applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. Our production adheres to cGMP guidelines where applicable, ensuring traceability and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.