Description

Piperazine-2,2,3,3,5,5,6,6-D8 Dihydrochloride is a high-purity, deuterium-labeled derivative of piperazine dihydrochloride, a crucial building block in pharmaceutical and biochemical research. This compound matters because its isotopic labeling provides a stable, non-radioactive tracer essential for advanced analytical techniques like mass spectrometry and NMR spectroscopy. It is primarily needed by researchers and manufacturers in the pharmaceutical industry for drug metabolism and pharmacokinetic (DMPK) studies, as well as by analytical laboratories developing reference standards for accurate quantification.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, isotopically labeled internal standard for the precise quantification of piperazine and its derivatives in complex biological matrices.
• Drug Metabolism Studies (DMPK): Used as a tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of drug candidates containing the piperazine moiety.
• Pharmaceutical Reference Standard: Provides a certified reference material for quality control and method validation in analytical laboratories.
• Biochemical Research: Enables mechanistic studies of enzymatic reactions and metabolic pathways where piperazine is a substrate or product.
• Stable Isotope Labeling: Acts as a starting material for the synthesis of more complex deuterated molecules for research and development.

Basic Information

Product Name	Piperazine-2,2,3,3,5,5,6,6-D8 Dihydrochloride
CAS No.	314062-45-8
Molecular Formula	C4H2D8Cl2N2
Molecular Weight	171.12 g/mol
Synonyms	Piperazine-d8 Dihydrochloride; Hexadeuteriopiperazine Dihydrochloride; Piperazine-2,2,3,3,5,5,6,6-octadeuterio Dihydrochloride; 1,4-Diazacyclohexane-d8 Dihydrochloride; Perdeuterated Piperazine Dihydrochloride; Piperazine (octadeutero) Dihydrochloride; Piperazine-D8 2HCl
EINECS	Contact for details

Quality Control

Our Piperazine-2,2,3,3,5,5,6,6-D8 Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic purity and chemical identity. We provide comprehensive Certificates of Analysis (COA) detailing assay, deuterium enrichment, and impurity profiles to ensure it meets the exacting standards required for research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Deuterium Enrichment	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.