Description

Ethyl 2-(2-Chloro-5-Nitrobenzamido)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of critical importance in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, especially in medicinal chemistry research.
• API Synthesis: Serves as a crucial precursor for the manufacture of complex Active Pharmaceutical Ingredients (APIs) with potential therapeutic applications.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex heterocyclic frameworks and studying structure-activity relationships (SAR).
• Preclinical & Clinical Development: Supplied in GMP-grade for use in the production of materials for toxicology studies and early-phase clinical trials.
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Detail
Product Name	Ethyl 2-(2-Chloro-5-Nitrobenzamido)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxylate
CAS No.	313233-80-6
Molecular Formula	C20H19ClN2O5S
Molecular Weight	434.89 g/mol
Synonyms	Ethyl 2-[(2-chloro-5-nitrobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate; 2-(2-Chloro-5-nitrobenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester; 4,5,6,7-Tetrahydro-2-[[(2-chloro-5-nitrophenyl)carbonyl]amino]benzo[b]thiophene-3-carboxylic acid ethyl ester; CAS 313233-80-6; 313233-80-6
EINECS	Contact for details

Quality Control

Our Ethyl 2-(2-Chloro-5-Nitrobenzamido)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.