Description

5-Bromo-3-((1-Methylpyrrolidin-2-Yl)Methyl)-1H-Indole is a high-purity, advanced pharmaceutical intermediate characterized by its unique indole scaffold substituted with a bromine atom and a methylpyrrolidinylmethyl group. This compound is of significant value for its role as a critical building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery and optimization of new therapeutic agents targeting the central nervous system and other disease areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially those with neurological or psychiatric activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new chemical entities.
• Chemical Biology Probe Development: Serves as a scaffold for creating tool compounds to study biological pathways and protein functions.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of active pharmaceutical ingredients (APIs) under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	5-Bromo-3-((1-Methylpyrrolidin-2-Yl)Methyl)-1H-Indole
CAS No.	312949-16-9
Molecular Formula	C₁₄H₁₇BrN₂
Molecular Weight	293.20 g/mol
Synonyms	5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole; 1H-Indole, 5-bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-; 5-Bromo-3-((1-methylpyrrolidin-2-yl)methyl)indole; 5-Bromo-3-(1-methylpyrrolidin-2-ylmethyl)indole; 312949-16-9; 5-Bromo-3-[(1-methylpyrrolidin-2-yl)methyl]-1H-indole
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-3-((1-Methylpyrrolidin-2-Yl)Methyl)-1H-Indole adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development and commercial projects with material that can be supplied under quality agreements, meeting the standards required for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.