Description

Sodium Fumarate-2,3-13C2 is a stable isotope-labeled derivative of sodium fumarate, specifically enriched with carbon-13 at the 2 and 3 positions. This high-purity labeled compound is essential for advanced analytical and metabolic research, providing a critical tracer for precise quantification and pathway elucidation. It is primarily required by research institutions, pharmaceutical developers, and analytical laboratories engaged in isotope dilution mass spectrometry (IDMS), NMR spectroscopy, and studies of cellular metabolism and pharmacokinetics.

Application

• Isotope Dilution Mass Spectrometry (IDMS): Serves as a high-purity internal standard for the accurate quantification of fumaric acid and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Used in in vitro and in vivo studies to track the incorporation of carbon atoms in the citric acid (Krebs) cycle and related biosynthetic pathways.
• NMR Spectroscopy: Provides a distinct signal for carbon-13 nuclear magnetic resonance studies, enabling detailed structural and dynamic analysis in chemical and biochemical systems.
• Pharmaceutical Research & Development: Facilitates drug metabolism and pharmacokinetic (DMPK) studies to understand the fate of new chemical entities within biological systems.
• Clinical Diagnostics Development: Employed in the development of advanced assays for diagnosing inborn errors of metabolism related to fumarate metabolism.
• Nutritional and Biochemical Research: Used to investigate the role of fumarate in cellular energy production, signaling, and its potential therapeutic applications.

Basic Information

Product Name	Sodium Fumarate-2,3-13C2
CAS No.	312623-83-9
Molecular Formula	C213C2H2Na2O4 or C4H2Na2O4 (with 13C at positions 2 & 3)
Molecular Weight	~162.04 g/mol (exact mass depends on enrichment level)
Synonyms	Disodium (2,3-13C2)fumarate; Fumaric Acid-2,3-13C2 Disodium Salt; (2E)-But-2-enedioic-2,3-13C2 acid disodium salt; 13C2-Labeled Sodium Fumarate; Sodium (E)-2-butenedioate-2,3-13C2; Isotopically Labeled Sodium Fumarate; [13C2]-Sodium Fumarate
EINECS	Contact for details

Quality Control

Every batch of Sodium Fumarate-2,3-13C2 is manufactured and analyzed under strict quality protocols to ensure exceptional isotopic and chemical purity, critical for sensitive research applications. Our quality commitment includes verification of isotopic enrichment (typically ≥99 atom % 13C) and chemical purity by advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, isotopic purity, identity, and impurities is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive). Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term stability, consider storage under an inert atmosphere in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	13C NMR spectrum confirms labeling at positions 2 & 3
Assay (HPLC)	≥98.0% (on anhydrous basis)
Isotopic Purity	≥99 atom % 13C
Chemical Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.