Description

(E)-3-(4-Bromophenyl)-2-(1-Methyl-1H-Benzo[D]Imidazol-2-Yl)Acrylonitrile is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular architecture combining a bromophenyl group with a benzimidazole core. This compound matters for its critical role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. Pharmaceutical companies, contract research organizations (CROs), and fine chemical manufacturers need it for developing potential drug candidates targeting various therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel small-molecule drug candidates, particularly those targeting kinase inhibition or other protein-protein interactions.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop compounds with improved potency and selectivity.
• Organic Light-Emitting Diode (OLED) Materials: Potential application as an electron-transporting or host material in OLED devices due to its conjugated acrylonitrile and heterocyclic structure.
• Agrochemical Research: Acts as a synthetic intermediate for developing new active ingredients with herbicidal or fungicidal properties.
• Fluorescent Probe Development: The benzimidazole and extended π-system make it a candidate scaffold for developing sensors and imaging agents.
• Academic & Industrial R&D: Utilized in chemical libraries for high-throughput screening to discover new bioactive compounds.

Basic Information

Item	Details
Product Name	(E)-3-(4-Bromophenyl)-2-(1-Methyl-1H-Benzo[D]Imidazol-2-Yl)Acrylonitrile
CAS No.	307533-98-8
Molecular Formula	C₁₇H₁₂BrN₃
Molecular Weight	338.20 g/mol
Synonyms	(E)-3-(4-Bromophenyl)-2-(1-methyl-1H-benzimidazol-2-yl)acrylonitrile; 2-[(1E)-2-Cyano-2-(4-bromophenyl)ethenyl]-1-methyl-1H-benzimidazole; (E)-3-(p-Bromophenyl)-2-(1-methyl-1H-benzimidazol-2-yl)acrylonitrile; 307533-98-8; (E)-3-(4-Bromophenyl)-2-(1-methyl-1H-benzoimidazol-2-yl)acrylonitrile; (E)-3-(4-Bromophenyl)-2-(1-methylbenzimidazol-2-yl)acrylonitrile; (E)-3-(4-Bromophenyl)-2-(1-methyl-1H-benzo[d]imidazol-2-yl)acrylonitrile
EINECS	Contact for details

Quality Control

Our (E)-3-(4-Bromophenyl)-2-(1-Methyl-1H-Benzo[D]Imidazol-2-Yl)Acrylonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC, to ensure compliance with exacting standards for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.