Description

(E)-3-(4-Fluorophenyl)-2-(1-Methyl-1H-Benzo[D]Imidazol-2-Yl)Acrylonitrile is a high-value, non-racemic synthetic intermediate characterized by its distinct acrylonitrile and benzimidazole pharmacophores. This compound matters for its role as a critical building block in the development of targeted pharmaceutical agents, particularly in kinase inhibitor research and other small-molecule therapeutic programs. Industrial and academic researchers in medicinal chemistry and process development need this material for lead optimization, structure-activity relationship (SAR) studies, and scaling novel synthetic routes.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential kinase inhibitors and other biologically active molecules.
• Medicinal Chemistry Research: Used in lead compound optimization and structure-activity relationship (SAR) studies due to its defined stereochemistry and functional groups.
• Chemical Biology Probes: Employed in the development of molecular probes to study enzyme function and cellular signaling pathways.
• Process Chemistry & Scale-Up: Acts as a defined starting material for the development and optimization of scalable GMP synthesis routes for active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in universities and research institutes for novel organic methodology development and heterocyclic chemistry studies.
• Custom Synthesis Building Block: Supplied for contract research organizations (CROs) and CDMOs engaged in custom synthesis projects for clients.

Basic Information

Product Name	(E)-3-(4-Fluorophenyl)-2-(1-Methyl-1H-Benzo[D]Imidazol-2-Yl)Acrylonitrile
CAS No.	307533-94-4
Molecular Formula	C18H14FN3
Molecular Weight	291.33 g/mol
Synonyms	(E)-3-(4-Fluorophenyl)-2-(1-methyl-1H-benzimidazol-2-yl)acrylonitrile; 2-[(1E)-2-Cyano-2-(4-fluorophenyl)ethenyl]-1-methyl-1H-benzimidazole; 307533-94-4; (E)-2-(1-Methyl-1H-benzo[d]imidazol-2-yl)-3-(4-fluorophenyl)acrylonitrile; 3-(4-Fluorophenyl)-2-(1-methyl-1H-benzimidazol-2-yl)-2-propenenitrile, (E)-; Acrylonitrile, 3-(4-fluorophenyl)-2-(1-methyl-1H-benzimidazol-2-yl)-, (E)-
EINECS	Contact for details

Quality Control

Our (E)-3-(4-Fluorophenyl)-2-(1-Methyl-1H-Benzo[D]Imidazol-2-Yl)Acrylonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >95% by HPLC), and impurity profile is provided with every shipment. Specifications can be aligned with ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% ee (E-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.